P-054. Leukaemia inhibitory factor concentration in follicular fluid: a marker of oocyte quality?

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Leukaemia inhibitory factor expression in human follicular fluid.

Leukaemia inhibitory factor expression in human follicular fluid Dear Sir, We were interested to read the paper by Arici et al. (1997) who found leukaemia inhibitory factor (LIF) expression in human follicular fluid (hFF). We would like to confirm this fact and make some short comments. Since we have postulated that LIF could play a role in the inflammatory-like processes involved in the periov...

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Follicular fluid concentration of leukaemia inhibitory factor is decreased among women with polycystic ovarian syndrome during assisted reproduction cycles.

BACKGROUND The possibility that a specific cytokine profile could be detected in the ovaries of patients with polycystic ovarian syndrome (PCOS) was investigated. METHOD Enzyme-linked immunosorbent assay (ELISA) or bioassays were used to assess the concentrations of leukaemia inhibitory factor (LIF), tumour necrosis factor, interleukin 11, gamma interferon, progesterone and oestradiol in foll...

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Leukaemia inhibitory factor expression in human follicular fluid and ovarian cells.

Leukaemia inhibitory factor (LIF) is a 43 kDa glycoprotein with a remarkable range of biological actions in different tissue systems. LIF improves the rate of fertilization of mouse oocytes in vitro and up-regulates aromatase enzyme. We postulated that LIF may be an important modulator of ovarian function and may also improve embryo quality in humans. Follicular fluid samples from patients unde...

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Concentration of leukaemia inhibitory factor (LIF) in uterine flushing fluid is highly predictive of embryo implantation.

BACKGROUND There is strong evidence that locally secreted cytokines control the implantation process and can cause implantation failure. Uterine flushing fluids were analysed to determine their concentrations of leukaemia inhibitory factor (LIF) and tumour necrosis factor (TNF). METHODS AND RESULTS We began by flushing the uterine cavities of 33 infertile patients on day 26 of two consecutive...

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Follicular Fluid Oocyte/Cumulus-Free DNA Concentrations as a Potential Biomolecular Marker of Embryo Quality and IVF Outcome

The present prospective study examined the follicular fluid oocyte/cumulus-free DNA concentrations (ff o/c-free DNA) during ovarian stimulation and the possible association between ff o/c-free DNA and embryological results such as embryo quality and pregnancy rate. Eighty-three women undergoing IV/ICSI-ET treatments were prospectively included in this study. ff o/c-free DNA was determined by co...

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ژورنال

عنوان ژورنال: Human Reproduction

سال: 1997

ISSN: 1460-2350,0268-1161

DOI: 10.1093/humrep/12.suppl_2.145-a